In Ghana, Mangoproduction is the major cash crop activityin the Yilo Krobo Municipality.However, the productivity of thecrop has been persistently lowover the past years. Studies have suggested that one key factor of productivity growth is efficiency in resource and technology use. This study estimated the economic efficiency of mango production to determine the scope for anincrease in mango production usingthe existing technology. A multistage sampling technique was used to randomly select and collect primary data from sixty two registered mango farmers. Stochastic production frontier analysis was used to estimatethe economic efficiencies and their determinants among mango farmers. The results of the analysis indicated that mango farmers were technically, allocativelly and economically inefficient, and that the presence of technical allocative and economicinefficiencies had effects on mango production. In addition, the results revealed that farm-specific and farmer-specific characteristics were significant predictors of the technical, allocative and economic inefficiency levels exhibitedby mango farmers. Furthermore, farmers exhibited increasing returns to scale. Based on these findings, policy makers should focus on promoting efficient use of existing technology and resources in mango production. The Ministry of Food and Agriculture should develop an integrated and holistic extension strategy to provide training for famers on resource use efficiency, information, and access to inputs and services.